Abstract
A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC50 value of 0.54 ± 0.01 ppm. © 2009 by the authors; licensee Molecular Diversity Preservation International.
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Zhan, C. W., Yi, M. L., Dan, Q. F., Cai, H. K., Lin, P., Chong, L. Y., & De Chen, J. (2009). A new atisane-type diterpene from the bark of the mangrove plant Excoecaria Agallocha. Molecules, 14(1), 414–422. https://doi.org/10.3390/molecules14010414
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