Minimum Inhibitory Concentration and Antibiotic Sensitivity Patterns in Pediatric Patients With Urinary Tract Infections

Abstract

Background Clinical professionals find it challenging to set uniform standards for the treatment of urinary tract infections (UTIs) because of differences in susceptibility. This study has been conducted to assess antibiotic sensitivity patterns and bacterial profiles in pediatric patients with UTI and aid in the empirical management of patients exhibiting UTI symptoms. Materials and methods This is an observational prospective study conducted at the Department of Pediatric Surgery at Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India. Overall, 384 patients were enrolled in the study. Ethical approval was obtained from the Institutional Ethics Committee (IEC), RIMS, Ranchi, Jharkhand, India, under letter number 308 dated April 4, 2024. Results There was no significant difference in age groups between male and female participants. Various bacterial pathogens were detected in pediatric UTIs, including Escherichia coli, Proteus species, Klebsiella species, Enterobacter species, Serratia species, Citrobacter species, and Pseudomonas species. Escherichia coli was more sensitive to ertapenem (135 (93.1%)) and meropenem (130 (89.6%)), followed by amikacin (118 (81.3%)), nitrofurantoin (115 (79.3%)), and imipenem (111 (76.5%)). Conclusion Different antibiotics have shown different levels of sensitivity toward various strains of bacterial pathogens causing UTIs. It is recommended that antibiotics as a medication be suggested on the basis of antibiotic sensitivity patterns in different cases of UTIs. Also, regional data may be effective in the selection of suitable drugs.