Towards automated in vivo parcellation of the human cerebral cortex using supervised classification of magnetic resonance fingerprinting residuals

Abstract

Background: Accurate parcellation of the cerebral cortex in an individual is a guide to its underlying organization. The most promising in vivo quantitative magnetic resonance (MR)-based microstructural cortical mapping methods are yet to achieve a level of parcellation accuracy comparable to quantitative histology. Methods: We scanned 6 participants using a 3D echo-planar imaging MR fingerprinting (EPI-MRF) sequence on a 7T Siemens scanner. After projecting MRF signals to the individual-specific inflated model of the cortical surface, normalized autocorrelations of MRF residuals of vertices of 8 microstructurally distinct areas (BA1, BA2, BA4a, BA6, BA44, BA45, BA17, and BA18) from 3 cortical regions were used as feature vector inputs into linear support vector machine (SVM), radial basis function SVM (RBF-SVM), random forest, and k-nearest neighbors supervised classification algorithms. The algorithms' prediction performance was compared using: (i) features from each vertex or (ii) features from neighboring vertices. Results: The neighborhood-based RBF-SVM classifier achieved the highest prediction score of 0.85 for classification of MRF residuals in the central region from a held-out participant. Conclusions: We developed an automated method of cortical parcellation using a combination of MR fingerprinting residual analysis and machine learning classification. Our findings provide the basis for employing unsupervised learning algorithms for whole-cortex structural parcellation in individuals.