Evaluation the Effectiveness of Nephelium Lappaceum (Nl) Peel Aqueous Extract Against Kidney Dysfunction Induced by Thioacetamide (TAA) in Male Albino Rats

Abstract

Antioxidant system is one of the most important defense mechanisms in the body to reduce the effect of oxidative stress and reactive oxygen species (ROS). Thioacetamide (TAA) is a toxic substance which involved in many toxic effects on different body cells. the current study aimed to know the protective role of Nephelium lappaceum (NI) peel aqueous extract against functional and histological renal injury which induced by TAA in male's albino rats. Forty adult males rats were used for this study and randomly divided into equal 4 groups (10 animals per group), First negative (G1) group was given distilled water, second positive group (G2) was IP injected with 200 mg/kg inter of TAA twice a week, while the third group (G3) was gavage 25 mg/kg NI, the last group (G4) taken 200 mg/kg of TAA and 25 mg/kg (NI), After 12 weeks, the following parameters were measure Malondialdehyde (MDA), Glutathione (GSH), the effectiveness of the enzyme Superoxide dismutase (SOD), urea and creatinine, in addition to study the histological changes to evaluation the effectiveness of Nephelium lappaceum (NI) peel aqueous extract. the result showed that treatment with NI enhance normal kidney function as well as show its effectiveness against renal damage and renal abnormalities.