Immunomodulatory effects of glutathione, garlic derivatives, and hydrogen sulfide

Abstract

Glutathione and aged garlic extract are sulfur-containing products that play important protective and regulatory roles within the immune system and in oxidative processes. Hydrogen sulfide (H 2 S), an endogenous, gaseous, signaling transmitter, has also been shown to be involved in the regulation of inflammation. Recent studies have shown that sulfur-containing compounds from garlic have beneficial effects in attenuating outcomes associated with cardiovascular disease and inflammation by a mechanism that may be related to the H 2 S signaling pathway. In this review, we summarize the main functions of glutathione (GSH), garlic derivatives and H 2 S and their role in the immune response and impact on health and disease.