Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates

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Abstract

A novel high yielding, enantio- and diastereoselective protocol for the synthesis of α-allylated highly functionalised β-amino acid derivatives by adding isoxazolidin-5-ones to MBH carbonates under asymmetric phase-transfer catalysis has been developed.

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Capaccio, V., Zielke, K., Eitzinger, A., Massa, A., Palombi, L., Faust, K., & Waser, M. (2018). Asymmetric phase-transfer catalysed β-addition of isoxazolidin-5-ones to MBH carbonates. Organic Chemistry Frontiers, 5(22), 3336–3340. https://doi.org/10.1039/c8qo01057a

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