Efficacy of photodynamic therapy in circumscribed choroidal haemangioma

Abstract

Purpose. To report efficacy of photodynamic therapy (PDT) in the treatment of three cases of juxtafoveal circumscribed choroidal haemangioma. Methods. Data on three patients (two primary, and one failed TTT) treated with verteporfin, 6 mg/m2 given as i.v. infusion over 10 min. Diode laser (690 nm) with an intensity of 600 mW/cm2 for 83 s (50 mJ/cm2) was applied 5 min after completion of infusion. Overlapping multiple spots (2500 μm) were applied to cover the entire surface of the tumour. The mean pretreatment tumour size was 7 mm (base) × 2.2 (thickness) mm. Periodic follow-up with ophthalmoscopy, ultrasonography, and angiographic studies was performed. Results. All three cases showed complete regression of the tumour with resolution of subretinal fluid, flattening of tumour, and absence of choroidal vasculature on ICG. The visual acuity either improved or remained stable in all three cases. The overlying retinal vessels remained unaffected. There were no ocular or systemic complications. Conclusions. PDT is an effective treatment for management of juxtafoveal circumscribed choroidal haemangioma. © 2004 Nature Publishing Group. All rights reserved.