Comparison of latanoprost, brimonidine tartrate, and bimatoprost plus timolol maleate in fixed combinations

Abstract

Aim: To compare the intraocular pressure (IOP)-lowering efficacy of fixed-combination antiglaucoma agents, and to evaluate the effect of these drugs on the visual field and optic disk morphology. Materials and methods: Included in this retrospective study were 17 eyes receiving latanoprost 0.005% + timolol maleate 0.5% fixed combination (group 1), 18 eyes receiving brimonidine tartrate 0.2% + timolol maleate 0.5% fixed combination (group 2), and 16 eyes receiving bimatoprost 0.03% + timolol maleate 0.5% fixed combination (group 3), all with the diagnosis of primary open-angle glaucoma or ocular hypertension. Intraocular pressure was measured by Goldmann applanation tonometer, a visual field test was performed, and optic disk morphology was evaluated by optic coherence tomography before the initiation of treatment and at the end of the follow-up period. The results were compared statistically. Results: All 3 fixed-combination drugs reduced IOP significantly compared to the baseline (for all groups, P < 0.001), although it was more pronounced in the group receiving the bimatoprost 0.03% + timolol maleate 0.5% fixed combination. No significant change was seen in the visual field and optic disk morphology in any group. Conclusion: All 3 fixed combinations are effective in lowering IOP and preserving the visual field and optic disk morphology. © TÜBİTAK.