P01-306-Adhd, gender, and psychiatric comorbidity in a populaiton-based birth cohort

  • Yoshimasu K
  • Barbaresi W
  • Colligan R
  • et al.
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Abstract

INTRODUCTION<br />ADHD is frequently associated with comorbid psychiatric disorders. However, epidemiologic studies in the general population are rare. <br /><br />OBJECTIVE<br />To evaluate associations between ADHD and comorbid psychiatric disorders using research-identified incident ADHD cases and population-based controls. <br /><br />METHOD<br />Subjects included a birth cohort of all children born 1976-1982 remaining in Rochester, MN after age five (n=5718). Among them we identified 379 ADHD incident cases and 758 age-sex matched non-ADHD controls, passively followed to age 19. Through a systematic, multistaged process, utilizing detailed, routinely collected data, all psychiatric diagnoses confirmed by medical professionals were identified (n=314 ADHD cases, n=712 controls with research authorization). For each psychiatric disorder, cumulative incidence rates for subjects with and without ADHD were calculated; corresponding hazard ratios (HR) adjusted for sex, mothers age/education, were estimated using a Cox model. Associations between ADHD status and Internalizing-Externalizing dimensions were estimated using odds ratios (OR). <br /><br />RESULTS<br />ADHD was associated with significantly increased risk for adjustment disorders (HR=3.82), conduct disorder/oppositional defiant disorder (HR=9.45), mood disorders (HR=3.57), anxiety disorders (HR=2.95), tic disorders (HR=6.41), eating disorders (HR=5.52), personality disorders (HR=5.49), and substance-related disorders (HR=4.04). When psychiatric comorbidities were classified on the Internalizing-Externalizing dimension, ADHD was strongly associated with coexisting internalizing/externalizing (OR=10.6, vs none), and externalizing-only (OR=10.0), disorders. No significant gender x ADHD interactions were observed. <br /><br />CONCLUSION<br />This population-based study confirms that children with ADHD are at significant risk for co-morbid psychiatric disorders. Besides treating the ADHD, clinicians should assess and monitor potential psychiatric comorbidities in children with ADHD.

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Yoshimasu, K., Barbaresi, W. J., Colligan, R. C., Killian, J. M., Voigt, R. G., Weaver, A. L., & Katusic, S. K. (2011). P01-306-Adhd, gender, and psychiatric comorbidity in a populaiton-based birth cohort. European Psychiatry, 26, 308. https://doi.org/10.1016/s0924-9338(11)72017-x

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