Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium

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Abstract

In order to gain insights into the regulatory control of neuronal diversity in the mammalian olfactory system, we have identified the transcriptional profile of individual olfactory neurons. A single cell microarray strategy was performed to search for candidate genes involved in the molecular specification of dorso-ventral zones of olfactory receptor (OR) expression. Several transcripts were identified that display differential expression in distinct OR zones, including a novel family of genes, the Lozenge-like (Lzl) genes which share sequence consensus motifs with Lozenge, a transcription factor involved in the patterning of the Drosophila olfactory and visual systems. © UBC Press.

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Tietjen, I., Rihel, J., & Dulac, C. G. (2005). Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium. International Journal of Developmental Biology, 49(2-3 SPEC. ISS.), 201–207. https://doi.org/10.1387/ijdb.041939it

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