Synthesis and in vitro antimicrobial activity of novel 2-(4-(substituted- carboxamido)benzyl/phenyl)benzothiazoles

Abstract

A new series of 2-[4-(4-substitutedbenzamido/phenylacetamido/ phenylpropionamido) benzyl/phenyl]benzothiazole derivatives (6a-6w) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 200 and 6.25 μg/ml. Compounds 6e and 6j exhibited the greatest activity with MIC values of 6.25 μg/ml against Pseudomonas aeruginosa, and Staphylococcus aureus isolate, respectively.