Targeting metabolic cross talk between cancer cells and cancer-associated fibroblasts

Abstract

Considering metabolic cross talk between CAFs and cancer as a metabolic target for cancer therapyTargeting the reverse Warburg effects via disruption of the “lactate shuttle” by MCT1/MCT 4 inhibitorsBlocking the function of CAFs, which promote cancer cell growth, by metforminUsing metformin to inhibit glycolysis of CAFsTargeting glutaminolysis by blocking the glutamine uptake of cancer cells from CAFsTargeting ketone bodies and ketosis in CAFsTargeting fatty acid metabolism, as a nutrient reservoir for cancer cell growth, from cancer-associated adipocytes (CAAs).