Biomarkers of Endothelial, Renal, and Platelet Dysfunction in Stage 5 Chronic Kidney Disease Hemodialysis Patients With Heart Failure

Abstract

The aim of this study was to determine the role of endothelial, renal, and inflammatory biomarkers in the pathogenesis of heart failure (HF) in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD). Plasma levels of biomarkers—kidney injury molecule 1 (KIM-1), N-terminal pro brain natriuretic peptide (NT-proBNP), glycated hemoglobin, neutrophil gelatinase–associated lipocalin, interleukin-18,platelet-derived growth factor, platelet factor 4 (PF4), 25-OH vitamin D, parathyroid hormone (PTH), endothelin, and endocan—were measured in CKD5-HD patients at the Loyola University Ambulatory Dialysis facility. The HF (+) CKD5-HD patients, as compared to HF (−) CKD5-HD patients, exhibited significantly elevated NT-proBNP (P =.0194) and KIM-1 (P =.0485). The NT-proBNP in HF (+) CKD5-HD patients was found to correlate with the levels of serum potassium (P =.023, R = −.39), calcium (P =.029, R = −.38), and PF4 (P =.045, R = −.35). The KIM-1 in HF (+) CKD5-HD patients was found to correlate with PTH (P =.043, R = −.36) and 25-OH vitamin D (P =.037, R =.36). Elevated plasma NT-proBNP and KIM-1 in CKD5-HD and HF (+) CKD5-HD patients suggest that natriuretic peptides and KIM-1 may contribute to the pathogenesis of HF in CKD5-HD patients.