K-haler® breath-triggered inhaler: a profile of the properties of the device

Abstract

The k-haler® device is a new breath-triggered pressurized metered-dose inhaler (BTI). Its breath-triggered mechanism employs unique ‘kinked-hose valve’ technology (k-valve™) and is easy to actuate. In vitro, the k-haler device required less respiratory power, which is affected by the resistance of the device, for dose release than a dry powder inhaler (DPI), potentially making it suitable for a wider range of patients, including those with a low inspiratory flow rate. It has a lower, more consistent plume force than conventional press-and-breathe pressurized metered-dose inhalers (pMDIs), has high fine-particle fraction and pulmonary deposition rates, and, in contrast to conventional pMDIs (but like other BTIs and DPIs), does not require actuation-inhalation coordination. The k-haler device is compact, has an easy-to-read dose counter, a connected mouthpiece and is simple to use, with limited data indicating that more patients are satisfied with the device than they are with some DPIs and that many patients prefer it over some commonly used inhalers. To facilitate correct use, the packaging of the k-haler contains simple how-to-use instructions and diagrams, as well as a patient information leaflet. A number of inhaled products may be suitable for administration via the k-haler device.