Screening Diospyros mespiliformis extract for antimalarial potency

Abstract

Diospyros mespiliformis is used in ethnomedical practice for treating malaria attack. The aqueous extract of the plant’s stem bark was investigated for in vivo antiplasmodial potency in mice. Curative effect against established infection, suppressive activity against early infection and prophylactic effect in residual infection were tested against Plasmodium berghei berghei infected mice. Result shows that the extract (50-200 mg/kg, p.o.) has significant (p