Phosphoinositide kinases play key roles in norepinephrineand angiotensin II-induced increase in phosphatidylinositol 4,5-bisphosphate and modulation of cardiac function

Abstract

Background: The mechanism and significance of phosphoinositide metabolism during heart stress stimulations are not clear. Results: Norepinephrine and angiotensin II increase cardiac phosphatidylinositol 4,5-bisphosphate levels via an enhanced interaction between phosphatidylinositol 4-kinase III and PKC, which correlate with a maintained systolic function. Conclusion: Cardiac phosphoinositide turnover is enhanced. Significance: A novel mechanism of phosphoinositide metabolism is described for modulation of cardiac function. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.