Detecting and managing patients with type 2 diabetic kidney disease: Proteinuria and cardiovascular disease

Abstract

Background. The increasing prevalence of type 2 diabetes (T2DM) places more patients at risk for developing chronic kidney disease (CKD) or cardiovascular (CV) events. Effective therapy for CKD or CV disease (CVD) requires a method of identifying affected patients and monitoring the effectiveness of therapy. Methods. We tested the predictive value of proteinuria for identifying patients at risk for progressive CDK and CVD, and monitoring treatment was determined using RENAAL study results. Results. Baseline proteinuria identified patients at risk for progressive CKD and CVD. Suppression of proteinuria was associated with decreased likelihood of CKD or CVD. Conclusion. Proteinuria identifies the risk of CKD and CVD, and can be used to monitor the effectiveness of therapy. © 2004 by the International Society of Nephrology.