Therapy of Experimental Brucella Infection in the Developing Chick Embryo

Abstract

The superiority of combined streptomycin-sulfadiazine therapy in developing chick embryos infected with Br. abortus, Br. suis, or Br. melitensis is due to a synergistic action of the two therapeutic agents. The relative ineffectiveness of streptomycin alone was apparently not due to the development of resistance by the infecting organism. This synergistic action of streptomycin and sulfadiazine provides supportive evidence for the use of combined therapy in human brucellosis.