Genome-wide analysis of known and potential tetraspanins in Entamoeba histolytica

9Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Tetraspanins are membrane proteins involved in intra-and/or intercellular signaling, and membrane protein complex formation. In some organisms, their role is associated with virulence and pathogenesis. Here, we investigate known and potential tetraspanins in the human intestinal protozoan parasite Entamoeba histolytica. We conducted sequence similarity searches against the proteome data of E. histolytica and newly identified nine uncharacterized proteins as potential tetraspanins in E. histolytica. We found three subgroups within known and potential tetraspanins, as well as subgroup-associated features in both their amino acid and nucleotide sequences. We also examined the subcellular localization of a few representative tetraspanins that might be potentially related to pathogenicity. The results in this study could be useful resources for further understanding and downstream analyses of tetraspanins in Entamoeba.

Cite

CITATION STYLE

APA

Tomii, K., Santos, H. J., & Nozaki, T. (2019). Genome-wide analysis of known and potential tetraspanins in Entamoeba histolytica. Genes, 10(11). https://doi.org/10.3390/genes10110885

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free