Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Abstract

The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10—16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (Fl) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to Fl allergen rose significantly in a considerable number of the vaccinccs. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination. © 1988, Cambridge University Press. All rights reserved.