Percutaneous implantation of the left ventricular partitioning device for chronic heart failure: A pilot study with 1-year follow-up

Abstract

Aims To assess short-term safety defined as the successful delivery and deployment of the ventricular partitioning device (VPD) implant, as well as 12-month functional, clinical, and haemodynamic effectiveness. Methods and results Ventricular partitioning device implantation was successful in 15/18 (83) patients with anteroapical regional wall motion abnormalities following myocardial infarction. In one patient, the VPD was removed 3 days post implantation and the patient subsequently died due to extra-cardiac sepsis. When compared with baseline, there was significant improvement at 6 and 12 months following VPD implantation in NYHA class (2.21 ± 0.57 vs. 1.28 ± 0.46 vs. 1.23 ± 0.4.3, respectively, P < 0.001 for both), left ventricular (LV) end-systolic volume (189 ± 45 vs. 142 ± 29 vs. 151 ± 48 mL/m2, respectively, P < 0.001 for both), and LV end-diastolic volume (260 ± 47 vs. 208 ± 33 vs. 222 ± 58 mL/m2, respectively, P < 0.001 for both). After 12 months, an improvement in LV ejection fraction was noted (28 ± 7 vs. 32 ± 7 vs. 33 ± 9, respectively, P = 0.02) as well as improvement in 6 min walk distance (382 ± 123 vs. 409 ± 7 vs. 425 ± 140 m) when compared with pre-procedural values. Conclusion Our data indicate that VPD implantation is safe and feasible, and that VPD implantation improves LV haemodynamics and functional capacity in the 12 months following the procedure. © 2010 The Author.