Anti-inflammatory potential of different extracts isolated from the roots of Ficus Lacor Buch. Hum and Murraya koenigii L. Spreng

Abstract

The present study was undertaken to evaluate the anti-inflammatory potential of Murraya koenigii root extracts petroleum ether, ethyl acetate and chloroform (MKPE , MKEA and MKCF, respectively) and Ficus lacor aerial root extracts petroleum ether, ethyl acetate, chloroform and ethanol (FLPE , FLET, FLCF and FLET, respectively) at doses of 50 and 100 mg/kg body weight (b.w.) using animal models of acute inflammation (carrageenan-, histamine- and serotonin-induced inflammation). The results of the Murraya koenigii roots chloroform extract caused 66.4% inhibition and the ethanol extract of Ficus lacor aerial roots caused 68.3% inhibition at the dose of 50 mg/kg b.w. At a higher dose of 100 mg/kg b.w., MKPE and MKCF showed 55.10% and 70.10% inhibition, respectively. FLPE and FLET showed 74.50% and 75.40% inhibition, respectively, in the carrageenan-induced inflammation model. In histamine-induced inflammation, the MKCF showed 60% inhibition, and 67.01% and 68.02% inhibition with the petroleum ether and ethanol extracts, respectively, in Ficus lacor aerial roots at the dose of 50 mg/kg b.w. At a higher dose (100 mg/kg b.w.), MKCF showed 64% inhibition. FLPE and FLET showed 70.13%and 74.01% inhibition, respectively; 62.15% and 66.10% inhibition was observed with the petroleum ether and ethanol extracts of Ficus lacor aerial roots at 50 mg/kg b.w. At higher dose (100 mg/kg b.w.), FLPE and FLET showed 69.10% and 68.72% inhibition in serotonin-induced inflammation.