A C-linked disaccharide analogue of Thomsen-Friedenreich epitope induces a strong immune response in mice

Abstract

Anticancer vaccine: Antigen 2 made out of a tripeptide of β-D-Galp-(1→3)-CH 2-α-D-GalNAc-O-Ser and conjugated with keyhole limpet hemocyanin (KLH) protein induced an early and strong immune response (IgG antibodies) in mice. Antigen 3 made out of an α-C- galactoside analogue did not induce such an immune response (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.