Screening in Women With BRCA Mutations Revisited

Abstract

Patients with BRCA1 or BRCA2 gene mutations are at high risk for the development of breast cancer.This article reviews the current evidence for breast cancer screening of patients with BRCA1 or BRCA2 pathogenic gene mutations if they have not undergone prophylactic mastectomy. It will review the current evidence-based imaging recommendations for different modalities and ages of screening initiation in screening this patient population at high risk. Special considerations in transgender BRCA1 and BRCA2 mutation carriers are also discussed.