New intermediates for the selective synthesis of 1-methyl-3- phenylpiperazine and some phenylpiperazine derivatives

Abstract

New intermediates, 4-protected-1-alkyl-2-oxo-3-phenylpiperazines (3a-e) and 1-alkyl-2-oxo-3-phenylpiperazines (6a-d) for the selective synthesis of 1-alkyl-3-phenylpiperazines (5a-e) are described. First method involves the reduction of the 4-protected-1-alkyl-2-oxo-3-phenylpiperazine (3a-e) followed by deprotection giving the 1-alkyl-3-phenylpiperazine (5a-e). Second method involves the deprotection of 4-protected-1-alkyl-2-oxo-3-phenylpiperazine (3a-e) followed by reduction giving the 1-alkyl-3-phenylpiperazine (5a-e). ©Arkat.