Total Synthesis of (±)-, −-,and (+)-Oudemansin X

Abstract

Three kinds of oudemansin X, (-)-1, (+)-1 and (±)-1, were totally synthesized. The key point in the present chiral synthesis was the enantioselective acetylation of the racemic alcohols, (±)-5 and (±)-8, using lipase in an organic solvent. The synthetic (—)-1 was found to exhibit strong antifungal activity against several molds and yeasts. © 1995, The Pharmaceutical Society of Japan. All rights reserved.