In a prospective case-control study of 127 normozoospermic and 435 non-normozoospermic Caucasian men, the genotype frequencies of a polymorphism of the interleukin-1 beta gene (IL-1β Taq C→T) were statistically significantly different between groups (homozygous wild-type C/C [57%], heterozygous C/T [42%], and homozygous mutant T/T [1%] vs. C/C [57%], C/T [36%], T/T [7%] for normozoospermic and non-normozoospermic men, respectively; odds ratio, 4.8; 95% confidence interval, 1.13 to 20.28). This association was restricted to men with the oligoasthenoteratozoospermia (OAT) syndrome. We conclude that the investigated polymorphism is associated with sperm pathology in Caucasians. © 2007 American Society for Reproductive Medicine.
CITATION STYLE
Bentz, E. K., Hefler, L. A., Denschlag, D., Pietrowski, D., Buerkle, B., & Tempfer, C. B. (2007). A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans. Fertility and Sterility, 88(3), 751–753. https://doi.org/10.1016/j.fertnstert.2006.11.174
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