Since erythromycin’ s the discovery in 1952 , it has been one of the most useful macrolide antibiotics, having the highest antibacterial activity and low toxicity. In order to achieve high antibacterial activities against a wide variety of pathogens and favorable pharmacokinetic properties, tremendous efforts have been made related to chemical modification [2, 3]. In the 1970s and 1980s, dirithromycin, flurithromycin, and davercin were synthesized and evaluated. Erythromycin itself is quite unstable under acidic conditions, so esters, salts, and various formulations also have been developed.
Adachi, T., & Morimoto, S. (2002). Clarithromycin and new derivatives of erythromycin. In Macrolide Antibiotics (pp. 53–72). Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8105-0_5