Tumor associated macrophages: A review with institutional study

Abstract

Aims: To study the expression of tumor-associated macrophages in different grades of squamous cell carcinoma and find the association between their expression and local recurrence, metastasis. Methodology: Thirty tumor biopsy samples of oral squamous cell carcinoma in T1N0M0 and T2N0M0 stages. Ten biopsy specimen of normal oral mucosa that are taken during minor oral surgical procedure with patient consent. Result: Macrophages were found to have better specificity for local recurrence, metastasis, and survival. Further, higher expression of biomarkers was associated with shorter survival. We have analyzed the differential expression of MMP 9 in different grades of OSCC & compare their expression with different TNM staging of tumors. Conclusions: Concluding this review of tumor-associated macrophages in comparison with OSCC cases. Since metastases are the principal cause of death in cancer patients, a greater understanding of the process of tumor invasion and metastasis is essential in leading to the identification of new therapeutic targets.