Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1a knockout mice

Abstract

Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1a knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1a knockout mice. These data suggest that skeletal muscle-PGC-1a is important for leucinemediated mTOR activation and protein biosynthesis.