Genome sequence and attenuating mutations in Nile virus isolate from Mexico

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Abstract

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

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Beasley, D. W. C., Davis, C. T., Estrada-Franco, J., Navarro-Lopes, R., Campomanes-Cortes, A., Tesh, R. B., … Barrett, A. D. T. (2004). Genome sequence and attenuating mutations in Nile virus isolate from Mexico. Emerging Infectious Diseases, 10(12), 2221–2224. https://doi.org/10.3201/eid1012.040647

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