Transglutaminases and neurodegeneration

77Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Transglutaminases (TGs) are Ca2+-dependent enzymes that catalyze a variety of modifications of glutaminyl (Q) residues. In the brain, these modifications include the covalent attachment of a number of amine-bearing compounds, including lysyl (K) residues and polyamines, which serve to either regulate enzyme activity or attach the TG substrates to biological matrices. Aberrant TG activity is thought to contribute to Alzheimer disease, Parkinson disease, Huntington disease, and supranuclear palsy. Strategies designed to interfere with TG activity have some benefit in animal models of Huntington and Parkinson diseases. The following review summarizes the involvement of TGs in neurodegenerative diseases and discusses the possible use of selective inhibitors as therapeutic agents in these diseases. © 2009 International Society for Neurochemistry.

Cite

CITATION STYLE

APA

Jeitner, T. M., Pinto, J. T., Krasnikov, B. F., Horswill, M., & Cooper, A. J. L. (2009). Transglutaminases and neurodegeneration. In Journal of Neurochemistry (Vol. 109, pp. 160–166). https://doi.org/10.1111/j.1471-4159.2009.05843.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free