Single-dose Treatment of Acute Urinary Tract Infection: A Controlled Trial

Abstract

Sulphormethoxine is a sulphonamide with a prolonged action, which makes possible the treatment of some varieties of acute urinary tract infection with a single dose of 2 g. In a controlled trial on ambulant patients it was as effective as a seven-day course of ampicillin given in a dose of 500 mg. eight-hourly. The cure rate was 88% with both substances. Side-effects occurred in 3.8% of patients treated with sulphormethoxine and in 16.1% of those who received ampicillin.Sulphormethoxine is not recommended for acute pyelonephritis. © 1967, British Medical Journal Publishing Group. All rights reserved.