Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder

Abstract

Since its inception in 2006, the Heinz C. Prechter Longitudinal Study of Bipolar Disorder has continued to actively enrol and follow a cohort of individuals with bipolar disorder and unaffected psychiatric controls with deep phenotyping and ongoing monitoring of symptom severity. There are 1393 individuals in the cohort and 899 who continue to actively provide ongoing bimonthly outcomes assessments. The average follow-up period is 9 years (range 0 7 years). The study includes data from seven ontological classes of phenotypes: disease, neuropsychology, personality, motivated behaviour, sleep and circadian rhythms, life story and treatment outcomes patterns. The database of measures has been standardized and harmonized along with collected biological samples that can be shared and further utilized to research bipolar disorder. In addition to further longitudinal outcomes and symptom severity measures, new measures include wearable device data, mobile technology assessments, voice-derived emotion annotation, induced pluripotent stem cells and diverse molecular omics data. All clinical, longitudinal, biological and deoxyribonucleic acid samples are available through the Heinz C. Prechter Genetic Repository, distributed by the University of Michigan Central Biorepository. Initial diagnostic evaluation, omics data and longitudinal measures and outcome data, including coded subsets of the PRIORI speech data set, are available via request at the following e-mail address: mmcinnis@umich.edu, prechter-data-request@med.umich.edu conditional on data-use agreement.