A case of hepatitis C-associated osteosclerosis in an elderly Japanese man

14Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

Hepatitis C-Associated Osteosclerosis (HCAO) is characterized by a marked increase in bone mass with deep bone pain. Since 1992, eleven cases of HCAO have been reported. This report describes an elderly Japanese man with HCAO, whose clinical course we followed for 3 years. A 68-year-old man developed pain in both pretibial regions in June 2000, and he had frequent episodic loss of muscular strength in his hands. He had recieved blood transfusion for a bleeding ulcer 43 years before and was seropositive for hepatitis C virus. His serum alkaline phosphatase (ALP) level was markedly increased, while his serum calcium was slightly decreased and serum phosphate was normal. Skeletal radiographs of the lower extremities showed a progressive increase in skeletal density, but did not show any apparent deformity. Administration of nonsteroidal anti-inflammatory drugs led to a reduction in bone pain. Treatment with vitamin D3 and calcium decreased the number of episodes of sudden muscular weakness and maintained serum calcium within the normal range. Three years after the onset of the disease, bone mineral density of his lumbar vertebrae and left hip rose from 0.963 g/cm2 to 1.096 g/cm2, and from 0.938 g/cm 2 to 1.383 g/cm2, respectively. His serum ALP level decreased from 2889 to 277 IU/L (normal range: 104-338) and serum calcium normalized. These findings were accompanied by a decrease in bone pain. This case and previous reports suggest that the skeletal tissue of this disease appears to be of good quality.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Tanaka, T., Oki, S., Muro, S., Tanaka, K., & Hashimoto, J. (2006). A case of hepatitis C-associated osteosclerosis in an elderly Japanese man. Endocrine Journal, 53(3), 393–399. https://doi.org/10.1507/endocrj.K04-131

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 6

55%

Researcher 4

36%

Lecturer / Post doc 1

9%

Readers' Discipline

Tooltip

Medicine and Dentistry 13

76%

Pharmacology, Toxicology and Pharmaceut... 2

12%

Social Sciences 1

6%

Sports and Recreations 1

6%

Save time finding and organizing research with Mendeley

Sign up for free