Receptor-evoked Ca2+ influx is mediated by store-operated Ca2+ channels, such as the CRAC channel, which mediates the Icrac current. Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates Icrac to prolong Ca2+ influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca2+ influx by the CRAC channel. © 2007 Elsevier Ltd. All rights reserved.
Muallem, S. (2007, July 17). Calcium Signaling: Pyruvate and CRAC Meet at the Crossroads. Current Biology. https://doi.org/10.1016/j.cub.2007.05.037