Calcium Signaling: Pyruvate and CRAC Meet at the Crossroads

Citations of this article
Mendeley users who have this article in their library.


Receptor-evoked Ca2+ influx is mediated by store-operated Ca2+ channels, such as the CRAC channel, which mediates the Icrac current. Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates Icrac to prolong Ca2+ influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca2+ influx by the CRAC channel. © 2007 Elsevier Ltd. All rights reserved.




Muallem, S. (2007, July 17). Calcium Signaling: Pyruvate and CRAC Meet at the Crossroads. Current Biology.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free