Camguk, lin-2, and CASK: Novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains

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Abstract

MAGUKs (membrane-assoiated guanylate kinase homologs) are proteins involved in cell junction organization, tumor suppression, and signalling. Their structure includes one or three copies of a DHR or PDZ domain (discs-large homologous region or PSD-95/SAP90, discs-large, ZO-1 homologous domain), an SH3 domain, and a guanylate kinase domain. MAGUKs were classified into two subfamilies: Dig-like with three DHR/PDZ domains and p55-like with a single DHR/PDZ domain. There is now a new subfamily whose members have a novel domain structure: a calcium/calmodulin-dependent protein kinase domain in the N-terminus as well as the DHR/PDZ, SH3 and GUK domains in the C-terminus. These new MAGUKs may regulate transmembrane molecules that bind calcium, calmodulin, or nucleotides. camguk (cmg) is a Drosophila member of this novel MAGUK subfamily; we report its sequence and domain structure.

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Dimitratos, S. D., Woods, D. F., & Bryant, P. J. (1997). Camguk, lin-2, and CASK: Novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains. Mechanisms of Development, 63(1), 127–130. https://doi.org/10.1016/S0925-4773(97)00668-0

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