Cancer of the esophagus; histopathological sub-types in northern Uganda

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Background: Esophageal cancer is the eighth most common cause of cancer death worldwide with squamous cell carcinoma\r<br />and adenocarcinoma carcinoma as the main histopathological subtypes. Esophageal cancer is known for its marked\r<br />variation by geographic region, ethnicity, and gender. Hitherto, the histopathological subtype of this cancer in Northern\r<br />Uganda were not known. Therefore the aim of the study was to describe the characteristics of esophageal cancer with respect\r<br />to the histopathologic subtypes, different sites of occurrence, age and gender in this region since its distribution varies\r<br />with location.\r<br />Methods: The study was carried out at Lacor Hospital, in northern part of Uganda. The record of 71 patients who had\r<br />endoscopic and histopathological diagnosis of cancer of esophagus over a period of 3 years between January 2009 and December\r<br />2011 were retrospectively analyzed.\r<br />Results: A total of 140 patients had endoscopic diagnosis of cancer of the esophagus and of these, 71 patients had both endoscopic\r<br />and histopathological diagnosis of cancer of esophagus during the three-year period covered in the study between\r<br />January 2009 to December 2011. The female to male ratio was 1:3 with mean age of 55.5 years ± SD 11.8. The common\r<br />histopathological pattern of cancer of esophagus was squamous cell carcinoma of esophageal consisting of 66 patients\r<br />(93.o%). The ratio of squamous cell carcinoma to adenocarcinoma was 13:1.The majority of the esophageal cancers were\r<br />found in the middle third with 38 patients (53.52%), followed by lower third with 27 patients (38.0%) and the upper third\r<br />which was only 6 patients (8.5%).\r<br />Conclussions: Squamous cell carcinoma is the most common histopathological subtype in this geographical location with\r<br />overall cancer of the esophagus mainly affecting the lower 2/3 of the esophagus with the majority in the middle third.\r<br />Key words: cancer of esophagus, histopathological subtypes, Uganda.




Alema, O. N., & Iva, B. (2014). Cancer of the esophagus; histopathological sub-types in northern Uganda. African Health Sciences, 14(1).

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