Capnocytophaga canimorsus sepsis in a methotrexate-treated patient with rheumatoid arthritis

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Abstract

Capnocytophaga canimorsus is a gram-negative rod that can be transmitted primarily by dog bites. This life-threatening organism commonly causes sepsis in patients with splenectomy or alcoholism. A 53-year-old rheumatoid arthritis male treated with methotrexate (MTX) for 5 years was admitted for a 4-day history of fever and dyspnea. He had been bitten on a finger by the family dog 4 days before onset. Laboratory tests revealed pancytopenia, acute renal failure, and evidence of disseminated intravascular coagulation, and he subsequently developed acute respiratory distress syndrome. Furthermore, blood cultures grew gram-negative bacilli and despite intensive treatment, he died 5 days after admission. Later, C. canimorsus was identified from his culture samples using a species-specific polymerase chain reaction. C. canimorsus infections should be considered in the differential diagnosis of sepsis for immunocompromised hosts following animal bites.

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Tamura, S., Koyama, A., Yamashita, Y., Shiotani, C., Nakamoto, H., Nakamoto, C., … Fujimoto, T. (2017). Capnocytophaga canimorsus sepsis in a methotrexate-treated patient with rheumatoid arthritis. IDCases, 10, 18–21. https://doi.org/10.1016/j.idcr.2017.08.002

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