Catalyst-free synthesis of benzodiazepines and benzimidazoles using glycerol as recyclable solvent

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Abstract

We described herein the use of glycerol as solvent in the catalyst-free synthesis of benzodiazepines and benzimidazoles. This simple and efficient method furnishes the corresponding 1-H-1,5-benzodiazepines and 1,2-disubstituted benzimidazoles in good yields by the condensation of o-phenylenediamine with several ketones and aldehydes, respectively. In addition, glycerol can be easily re-utilized for further condensation reactions up to four times without lost of activity. © 2011 Elsevier Ltd. All rights reserved.

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Radatz, C. S., Silva, R. B., Perin, G., Lenardão, E. J., Jacob, R. G., & Alves, D. (2011). Catalyst-free synthesis of benzodiazepines and benzimidazoles using glycerol as recyclable solvent. Tetrahedron Letters, 52(32), 4132–4136. https://doi.org/10.1016/j.tetlet.2011.05.142

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