Treatment of rats, experimentally infected with Strongyloides venezuelensis, by means of ivermectin by oral via

Abstract

Strongyloides venezuelensis experimental infection in rats was treated by two different oral preparations of invermectin, 0.2 mg/kg. One was a human formula used by WHO in the treatment of onchocerciasis; the other was a veterinary preparation. Adult worms and larvae were evaluated. The human formulation cleared both forms in 59.3% (adult worms) and 73.0% (larvae), whereas the veterinary one cleared 98.0% and 84.2%, respectively. The antilarval action is very useful when treating systemic strongyloidiasis.