Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
CITATION STYLE
Liao, M., Liu, Y., Yuan, J., Wen, Y., Xu, G., Zhao, J., … Zhang, Z. (2020). Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19. Nature Medicine, 26(6), 842–844. https://doi.org/10.1038/s41591-020-0901-9
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