Treatment of vulvar leukoplakia with theresienol - A new opportunity

Abstract

Introduction. The vulvar leukoplakia includes several diseases. The most common are vulvar lichen sclerosus and squamous cell hyperplasia of the vulva. These two conditions have many common features, but also have significant differences. Both of them have a risk of malignancy, and a risk of relapse after therapy. Cases presentations. We present four patients with clinically diagnosed vulvar leukoplakia. The therapy for all of them continued between two and three months, and subsequent one-year follow-up was carried out. The vulvar lichen sclerosus and squamous cell hyperplasia of the vulva have similar etiology, and clinical signs and symptoms, but different histopathological features, which also necessitate different therapeutic methods - conservative or surgical. All conservative therapeutic options have their side effects, while the surgical ones do not result in definite healing - the possibility of relapse of disease is present. In our cases, we observed rapid and stable response on the part of the clinical signs and symptoms with no complications. Conclusions. Due to disturbance of the quality of life upon manifested clinical presentation, the vulvar leukoplakia requires treatment. The therapy with TheresienOl is effective about the clinical symptoms, but only further follow-up and inclusion of new patients will show whether the risk of occurrence of vulvar cancer decreases.