The CpG island methylator phenotype in colorectal cancer

Abstract

In summary, this elegant study by Ogino et al performs an essential validation of the findings of Weisenberger et al and also points to some differences with the previous study that may have implications for the interpretation of CIMP results in the work-up of HNPCC. Much work still needs to be done with respect to the optimal technique(s) and panel(s) for CIMP determination, but the diagnostic utility and epidemiology of this epigenetic change strongly support its significance in the biology of colorectal cancer. Copyright © American Society for Investigative Pathology and the Association for Molecular Pathology.