Microarray analysis of intestinal immune-related gene expression in heat-stressed rats

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Abstract

Purpose: This study aimed to investigate immune-related gene expression in rat small intestine after heat stress. Materials and methods: Twelve Sprague Dawley (SD) rats were randomly divided into control and heat-stressed groups. Rats in both groups were housed at 25°C with 60% relative humidity. The heat-stressed group was subjected to 40°C for 2h/day for 3 days. After heat stress, the mRNA expression profile of small intestine epithelial tissue was evaluated by microarray analysis. Results: A total of 23 genes related to immune responses were significantly altered, of which 12 genes were up-regulated and 11 genes were down-regulated. Conclusions: Microarray analysis demonstrated the JAK-STAT pathway had a potentially important role in the regulation of inflammation in the small intestine, and changes in antigen presentation might reduce intestinal immune responses after heat stress. © 2014 Informa UK Ltd.

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Liu, X., Shi, Y., Hou, X., Wan, C., He, S., Chong, X., … Liu, F. (2014). Microarray analysis of intestinal immune-related gene expression in heat-stressed rats. International Journal of Hyperthermia, 30(5), 324–327. https://doi.org/10.3109/02656736.2014.939722

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