CD2ε{lunate} and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function

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Abstract

To determine whether CD3s and CD3s; proteins have unique roles in TCR-dependent functions, chimeric genes encoding the extracellular and transmembrane domains of the human IL-2 receptor a chain (Tac) fused to a cytoplasmic domain of either the CD3s or CD3ξ chain were Introduced as transgenes Into both normal and RAG2-defkaent (RAG2-1) mice. Developmental arrest of T lineage cells at the CD4, CD8 double-negative stage in the transgenic RAG-/- thymus was released to the CD4, COO double-positive (DP) stage by in vivo cross-linking of We or TTξ with anti-Tac antibody. In TTε{lunate}+ or TTξ+, RAG2-/- mice, in vitro cross-linking of TTε{lunate} and TTξ Induced DP thymocyte cell death and prolifenition of mature single-positive T cells. Overall, no qualitative differences were observed between TTε- and TTξ-mediated functions, suggesting that different CD3 components deliver qualitatively similar signals in inducing TCR-dependent functions. © 1995.

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Shlnkal, Y., Ma, A., Cheng, H. L., & Alt, F. W. (1995). CD2ε{lunate} and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function. Immunity, 2(4), 401–411. https://doi.org/10.1016/1074-7613(95)90148-5

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