Chiral bis(imidazolidine)pyridine-Cu complex-catalyzed enantioselective [3+2]-cycloaddition of azomethine imines with propiolates

Abstract

[3+2] Cycloaddition of azomethine imines with electron-deficient terminal alkynes was smoothly catalyzed by a chiral bis(imidazolidine)pyridine-CuOAc complex to give bicyclic pyrazolo[1,2-a]pyrazolone derivatives with up to 74% ee. © 2012 by the Authors.