Convenient and efficient method for the synthesis of n-heteroaryl aminonaphthols under solvent-free conditions

Abstract

A convenient, efficient and green synthesis of N-heteroaryl aminonaphthols has been developed by one-pot, three-component condensation of β-naphthol, heteroaryl amines and substituted benzaldehydes under solvent-free conditions at elevated temperature. The advantages of these reactions are simplicity of the reaction procedure, short reaction times, simple work-up, catalyst-free conditions and pure products in good to excellent yields. © 2010 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.