Studies on the constituents of Scutellaria species. XV. On the diterpenoid constituents of the leaves of Scutellaria alpina L.

Abstract

From the leaves of Scutellaria alpina L., four new neo-clerodane diterpenes (1-4) were isolated. The structures of 1-4 were shown to be (4S)-19-acetoxy-8β-hydroxy-6α-benzoyloxy-4,18-epoxy-neo-cleroda-11,1 3-dien-15,16-olide, (4S)-19-acetoxy-8β-hydroxy-6α-tigloyloxy-4,18-epoxy-neo-cleroda-11,1 3-dien-15,16-olide, (4S, 11S)-11-acetoxy-8β,19-dihydroxy-6α-tigloyloxy-4,18-epoxy-neo-clerod- 13-en-15,16-olide, and (4S)-19-acetoxy-8β-hydroxy-6α,7β-dibenzoyloxy-4,18-epoxy-neo-clerod a-11,13-dien-15,16-olide, respectively, by the chemical and spectral data.