DEPP was initially cloned from the human endometrial stromal cell cDNA library, but the transcriptional regulation of DEPP remains largely unknown. We demonstrate here that expression of DEPP is FoxO-dependent in human endothelial cells. Two functional FoxO-responsive elements are identified in the DEPP promoter. Hypoxia stimulates DEPP expression in the endothelial cell line EA.hy926. Hypoxia-induced upregulation of DEPP is dependent on FoxO expression. We conclude that DEPP is regulated at the level of transcription by FoxO in human vascular endothelial cells. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Chen, S., Gai, J., Wang, Y., & Li, H. (2011). FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells. FEBS Letters, 585(12), 1796–1800. https://doi.org/10.1016/j.febslet.2011.04.024